I have four 6tb data drives and 32gb of RAM. When I set them up with zfs, it claimed quite a few gb of RAM for its cache. I tried allocating some of the other NVMe drive as cache, and tried to reduce RAM usage to reasonable levels, but like I said, I found that I was spending a lot of time fiddling instead of just configuring RAID and have it running just fine in much less time.
That might be what was supposed to happen, but when I started up the VMs I saw memory contention.