If you don’t exceed a single deployment, it’s fine.

If however in the future, you want to add additional services to your host, let’s say an alerting or status system, it’s a lot easier to declare everything in a single place and then attach a reverse proxy to manage networking multiple services on one host.

As I use docker for most of my deploys (as you should for websites exposed to the Internet anyway), I can wholeheartedly recommend traefik for this. Basically it has the functionality of nginx, but supports easy Let’s Encrypt certificates.