Easily, I went from through several gen of pi and now run it on docker on my Synology.
As mentioned, it’s just a DNS server (at its core) and can actually make things faster as you will no longer download ads.
There are some getting used to things. Some url shorteners (constant contact) don’t work and sponsored Google search results won’t work. But the QOL is worth it.
That happens when you are a good developer too.